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Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective ...

2024-06-08 03:09:12 | bile

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bile: Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective ...

More bile news:

2024-02-07 08:00 Bile salt hydrolase acyltransferase activity expands bile acid diversity - Nature
2024-04-09 07:00 Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector ... - ScienceDirect.com
2019-08-28 07:00 The copper recycling pathway through bile - Pig Progress
2017-11-29 08:46 Bile reflux - Symptoms & causes - Mayo Clinic
2023-08-22 07:00 Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion ... - Nature
2021-01-05 05:39 Thematic Review Bile acids: the role of peroxisomes - ScienceDirect.com
2024-01-17 08:00 Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids - Nature
2023-11-30 08:00 Bile proteome reveals biliary regeneration during normothermic preservation of human donor livers - Nature
2023-06-07 07:00 Physiological activation of human and mouse bitter taste receptors by bile acids | Communications Biology - Nature

2023-10-13 07:00 Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling - Nature
2023-08-22 07:00 Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal ... - Nature
2024-02-07 08:00 Bile salt hydrolase catalyses formation of amine-conjugated bile acids - Nature
2024-04-26 07:00 Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets | Signal ... - Nature
2024-04-04 07:00 The changing metabolic landscape of bile acids – keys to metabolism and immune regulation - Nature
2023-06-20 07:00 Gut microbiota Turicibacter strains differentially modify bile acids and host lipids - Nature
2023-06-06 07:00 Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis - Nature
2024-03-01 08:00 Altered microbial bile acid metabolism exacerbates T cell-driven inflammation during graft-versus-host disease - Nature
2024-02-21 08:00 Another renaissance for bile acid gastrointestinal microbiology - Nature
2020-02-26 08:00 Global chemical effects of the microbiome include new bile-acid conjugations - Nature

2022-05-11 07:00 Structural basis of sodium-dependent bile salt uptake into the liver - Nature
2023-10-30 07:00 Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis - Nature
2021-06-24 07:00 Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species ... - Nature
2023-06-17 19:37 Bile - UF Health - University of Florida Health
2023-09-13 07:00 Bile salts enhance the susceptibility of the peach allergenic lipid transfer protein, Pru p 3, to in vitro gastrointestinal ... - Nature
2022-03-16 07:00 Human gut bacteria produce ΤΗ17-modulating bile acid metabolites - Nature
2023-04-01 07:00 Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and ... - Nature
2023-10-24 18:26 Combined inhibition of bile salt synthesis and intestinal uptake reduces cholestatic liver damage and colonic bile salts ... - ScienceDirect.com
2019-11-27 08:00 Bile acid metabolites control TH17 and Treg cell differentiation - Nature
2021-07-29 07:00 Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians - Nature

2023-03-13 07:00 Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut - Nature
2024-04-23 07:00 Multiscale X-ray phase-contrast CT unveils the evolution of bile infarct in obstructive biliary disease | Communications ... - Nature
2021-08-03 07:00 FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption - ScienceDirect.com
2017-10-11 07:00 Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis - Nature
2022-08-18 18:12 Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis - ScienceDirect.com
2022-08-22 07:00 A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity ... - Nature
2024-04-17 07:00 High temperature and humidity in the environment disrupt bile acid metabolism, the gut microbiome, and GLP-1 ... - Nature
2020-07-23 07:00 Bile acids drive the newborn’s gut microbiota maturation - Nature
2022-04-19 07:00 Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice - Nature
2022-05-17 07:00 Structural insights into the HBV receptor and bile acid transporter NTCP - Nature

2017-03-22 07:00 Cholesterol attenuates cytoprotective effects of phosphatidylcholine against bile salts | Scientific Reports - Nature
2022-11-02 07:00 Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation - Nature
2021-08-20 07:00 A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1 - ScienceDirect.com
2020-05-21 07:00 Thermodynamic interference with bile acid demicelleization reduces systemic entry and injury during cholestasis ... - Nature
2024-02-02 08:00 Discoveries of GPR39 as an evolutionarily conserved receptor for bile acids and of its involvement in biliary acute ... - Science | AAAS
2017-12-30 20:55 Bile Acids Induce Inflammatory Genes in Hepatocytes: A Novel Mechanism of Inflammation during Obstructive ... - ScienceDirect.com
2023-04-18 07:00 RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis | Cell ... - Nature
2022-10-19 07:00 Genome-centric investigation of bile acid metabolizing microbiota of dairy cows and associated diet-induced functional ... - Nature
2022-09-29 07:00 Anti-infective bile acids bind and inactivate a Salmonella virulence regulator - Nature
2017-12-27 01:28 Targeting bile-acid signalling for metabolic diseases - Nature

2022-05-17 07:00 Structure of the bile acid transporter and HBV receptor NTCP - Nature
2023-04-25 07:00 Emerging roles of bile acids in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma | Cellular & Molecular ... - Nature
2022-10-22 07:00 Bile acids profile and redox status in healthy infants | Pediatric Research - Nature
2024-01-30 08:00 Bile acid profiles in adult patients with biliary atresia who achieve native liver survival after portoenterostomy | Scientific ... - Nature
2022-09-07 07:00 Construction of a culture protocol for functional bile canaliculi formation to apply human iPS cell-derived hepatocytes ... - Nature
2022-07-01 07:00 What Is Bile Duct Cancer (Cholangiocarcinoma)? - NCI - National Cancer Institute (.gov)
2022-03-25 07:00 Metabolic Messengers: bile acids - Nature
2017-12-18 05:29 On the role of bile salts in the digestion of emulsified lipids - ScienceDirect.com
2024-01-29 08:00 Comprehensive bile acid pool analysis during ex-vivo liver perfusion in a porcine model of ischemia-reperfusion injury ... - Nature
2019-10-15 07:00 Bile acids in glucose metabolism and insulin signalling — mechanisms and research needs - Nature

2020-11-24 08:00 The pathophysiology of bile acid diarrhoea: differences in the colonic microbiome, metabolome and bile acids ... - Nature
2022-01-26 08:00 Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel - Nature
2022-05-18 07:00 A single faecal bile acid stool test demonstrates potential efficacy in replacing SeHCAT testing for bile acid diarrhoea in ... - Nature
2021-01-05 07:35 Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition - ScienceDirect.com
2024-03-12 07:00 Bile acids and the microbiome: revolutionising disease approaches - Drug Target Review
2022-06-21 07:00 Profiling gut microbiota and bile acid metabolism in critically ill children | Scientific Reports - Nature
2022-05-30 07:00 The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases - Nature
2022-06-20 07:00 Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver | Cell ... - Nature
2021-02-03 07:48 Circulating Bile Acids in Liver Failure Activate TGR5 and Induce Monocyte Dysfunction - ScienceDirect.com
2016-12-09 08:00 Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro ... - Nature

2020-03-18 07:00 Impaired bile acid metabolism with defectives of mitochondrial-tRNA taurine modification and bile acid taurine ... - Nature
2019-12-15 07:50 Reduced bile acid excretion is an independent risk factor for stroke and mortality: A prospective follow-up study - ScienceDirect.com
2023-12-06 08:00 Bile Duct Function and Disease Highlighted in New Research Study - Yale University
2021-02-23 08:00 Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors - Nature
2017-12-10 11:29 Bile acid receptors in the biliary tree: TGR5 in physiology and disease - ScienceDirect.com
2023-07-13 07:00 Bile acid binds heart failure and inflammation - Nature
2023-02-20 21:12 Different bile acids have versatile effects on sporulation, toxin levels and biofilm formation of different Clostridioides ... - ScienceDirect.com
2017-06-12 07:00 Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive ... - Nature
2020-10-28 07:47 Morphology of bile salts micelles and mixed micelles with lipolysis products, from scattering techniques and atomistic ... - ScienceDirect.com
2023-12-22 04:05 Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH ... - ScienceDirect.com

2020-01-30 01:34 A tandem mass spectrometric study of bile acids: Interpretation of fragmentation pathways and differentiation of steroid ... - ScienceDirect.com
2018-08-15 07:00 Complex bile duct network formation within liver decellularized extracellular matrix hydrogels | Scientific Reports - Nature
2022-02-14 08:00 Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology - Nature
2023-06-07 07:00 Impaired flux of bile acids from the liver to the gut reveals microbiome-immune interactions associated with liver ... - Nature
2020-08-03 07:00 Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein | Signal Transduction and ... - Nature
2019-09-26 14:01 Coordinated development of the mouse extrahepatic bile duct: Implications for neonatal susceptibility to biliary injury - ScienceDirect.com
2017-11-27 08:00 Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment - Nature
2021-09-02 18:30 Potential use of bile salts in lipid self-assembled systems for the delivery of phytochemicals - ScienceDirect.com
2019-07-22 07:00 Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome - Nature
2021-01-05 07:14 Microbial impact on cholesterol and bile acid metabolism: current status and future prospects - ScienceDirect.com

2020-07-25 18:36 Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis - ScienceDirect.com
2019-01-14 08:00 The bile salt glycocholate induces global changes in gene and protein expression and activates virulence in ... - Nature
2022-10-03 07:00 Increased concentrations of conjugated bile acids are associated with osteoporosis in PSC patients | Scientific Reports - Nature
2020-05-20 05:37 Retention of primary bile salts by dry beans (Phaseolus vulgaris L.) during in vitro digestion: Role of bean components ... - ScienceDirect.com
2020-05-15 12:54 Prebiotics may alter bile salt hydrolase activity: Possible implications for cholesterol metabolism - ScienceDirect.com
2017-12-16 13:52 Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing ... - ScienceDirect.com
2024-02-08 08:00 Mogrol stimulates G-protein-coupled bile acid receptor 1 (GPBAR1/TGR5) and insulin secretion from pancreatic β-cells ... - Nature
2018-11-21 08:00 Suppression of Hepatic Bile Acid Synthesis by a non-tumorigenic FGF19 analogue Protects Mice from Fibrosis and ... - Nature
2020-04-15 07:00 Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells - Nature
2016-01-07 08:00 Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective ... - Nature

2020-01-09 08:00 Bile acid bio-nanoencapsulation improved drug targeted-delivery and pharmacological effects via cellular flux: 6 ... - Nature

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