Small-Molecule Allosteric Triggers of Clostridium difficile Toxin B Auto-proteolysis as a Therapeutic Strategy

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ostridium difficile: Small-Molecule Allosteric Triggers of Clostridium difficile Toxin B Auto-proteolysis as a Therapeutic Strategy

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2023-09-21 07:00 La mayoría de las infecciones hospitalarias por Clostridium Difficile no se transmiten entre pacientes - infobae
2019-06-26 07:00 Revisan pruebas de amplificación de AN para el diagnóstico de Clostridium - LabMedica.es
2014-01-06 08:00 Epidemiología de la infección por Clostridium Difficile extrahospitalaria - IntraMed
2019-12-06 08:00 Avances contra la esquiva bacteria 'Clostridium difficile' - Biotech Magazine
2017-07-14 07:00 'Clostridium difficile' germina en ambientes ricos en calcio - Redacción Médica
2022-09-27 07:00 Clostridium difficile: Descripción de la patogenia - Porcicultura.com
2018-09-03 07:00 Guía de diagnóstico y tratamiento de la infección por Clostridium difficile - IntraMed
2016-09-15 07:00 Examinan exactitud de pruebas moleculares para Clostridium difficile - LabMedica.es
2023-12-07 08:00 Clostridium Difficile Tests Market Size by Segments, Share, Regulatory, Reimbursement, and Forecast to 2033 - GlobalData

2023-06-20 07:00 Current Challenges Surrounding Clostridium Difficile Infection - News-Medical.Net
2023-06-22 07:00 Multiplex genome engineering in Clostridium beijerinckii NCIMB 8052 using CRISPR-Cas12a | Scientific Reports - Nature
2023-05-08 07:00 New antibiotic may clear Clostridium difficile and stop reinfection - New Scientist
2021-11-01 07:00 Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues - Nature
2017-12-25 09:04 Clostridium difficile infection: new developments in epidemiology and pathogenesis - Nature
2019-09-05 07:00 Metagenomic and culturomic analysis of gut microbiota dysbiosis during Clostridium difficile infection | Scientific Reports - Nature
2017-09-05 07:00 Glucosyltransferase Activity of Clostridium difficile Toxin B Triggers Autophagy-mediated Cell Growth Arrest | Scientific ... - Nature
2021-07-22 07:00 Clostridium butyricum enhances colonization resistance against Clostridioides difficile by metabolic and immune ... - Nature
2016-05-11 07:00 Gut microbiota composition and Clostridium difficile infection in hospitalized elderly individuals: a metagenomic study ... - Nature
2019-08-12 07:00 Adaptation of host transmission cycle during Clostridium difficile speciation - Nature

2017-12-14 18:58 Regulation of Clostridium difficile spore germination by the CspA pseudoprotease domain - ScienceDirect.com
2018-01-03 08:00 Dietary trehalose enhances virulence of epidemic Clostridium difficile - Nature
2018-01-05 18:27 Treatment of Clostridium difficile-associated disease: old therapies and new strategies - ScienceDirect.com
2012-12-09 08:00 Emergence and global spread of epidemic healthcare-associated Clostridium difficile - Nature
2016-01-11 08:00 Crystal structure of Clostridium difficile toxin A - Nature
2017-12-25 19:09 Clostridium difficile carbohydrates: glucan in spores, PSII common antigen in cells, immunogenicity of PSII in swine and ... - ScienceDirect.com
2017-08-30 07:00 CD2068 potentially mediates multidrug efflux in Clostridium difficile | Scientific Reports - Nature
2019-08-05 07:00 Integrated genomic epidemiology and phenotypic profiling of Clostridium difficile across intra-hospital and community ... - Nature
2016-09-16 07:00 Reprofiled anthelmintics abate hypervirulent stationary-phase Clostridium difficile | Scientific Reports - Nature
2021-07-09 07:00 In silico designing of vaccine candidate against Clostridium difficile | Scientific Reports - Nature

2017-12-08 08:00 Surveillance of antibiotic resistance among common Clostridium difficile ribotypes in Hong Kong | Scientific Reports - Nature
2014-10-22 07:00 Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile - Nature
2018-09-17 07:00 Novel Clade C-I Clostridium difficile strains escape diagnostic tests, differ in pathogenicity potential and carry toxins on ... - Nature
2017-06-12 07:00 Clostridium difficile flagella induce a pro-inflammatory response in intestinal epithelium of mice in cooperation with ... - Nature
2019-04-17 14:00 Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection - ScienceDirect.com
2019-06-03 07:00 Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells - Nature
2017-11-25 21:16 The ClosTron: Mutagenesis in Clostridium refined and streamlined - ScienceDirect.com
2018-11-19 08:00 Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis - Nature
2014-09-01 07:00 Severe community onset healthcare-associated Clostridium difficile infection complicated by carbapenemase ... - BioMed Central
2016-08-30 07:00 Clostridium difficile colitis: pathogenesis and host defence - Nature

2019-06-20 07:00 IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection - Nature
2020-02-10 08:00 Diarrhoeal events can trigger long-term Clostridium difficile colonization with recurrent blooms - Nature
2018-08-01 14:26 The cost of Clostridium difficile infections • healthcare-in-europe.com - healthcare-in-europe.com
2019-04-03 07:00 Dual role of the colonization factor CD2831 in Clostridium difficile pathogenesis | Scientific Reports - Nature
2018-01-15 17:48 Immune responses to Clostridium difficile infection - ScienceDirect.com
2015-07-28 07:00 Mechanisms of hypervirulent Clostridium difficile ribotype 027 displacement of endemic strains: an epidemiological ... - Nature
2014-12-30 08:00 Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B | Cell Research - Nature
2017-12-24 22:11 Characterization of the collagen-like exosporium protein, BclA1, of Clostridium difficile spores - ScienceDirect.com
2012-03-09 08:00 Vital Signs: Preventing Clostridium difficile Infections - CDC
2022-08-31 07:00 Faecal transplants recommended for Clostridium difficile - BBC

2016-02-10 08:00 Breakthroughs in the treatment and prevention of Clostridium difficile infection - Nature
2018-09-17 07:00 Epitopes identified in GAPDH from Clostridium difficile recognized as common antigens with potential autoimmunizing ... - Nature
2018-07-23 07:00 Relationship between clostridium difficile infection and gastrointestinal graft versus host disease in recipients of ... - Nature
2020-10-13 07:00 Clostridium Difficile: An Intestinal Infection on the Rise - Harvard Health Publishing - Harvard University
2018-11-18 15:54 Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile ... - ScienceDirect.com
2017-02-03 08:00 Evolutionary clade affects resistance of Clostridium difficile spores to Cold Atmospheric Plasma | Scientific Reports - Nature
2011-07-15 07:00 Incidence of and risk factors for community-associated Clostridium difficile infection: A nested case-control study - BMC ... - BioMed Central
2016-04-19 07:00 Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans - Nature
2016-07-07 07:00 The efficacy of intracolonic vancomycin for severe Clostridium difficile colitis: a case series - BMC Infectious Diseases - BioMed Central
2017-12-20 03:35 Synthetic Lipoteichoic Acid Glycans Are Potential Vaccine Candidates to Protect from Clostridium difficile Infections - ScienceDirect.com

2017-08-23 07:00 Disparate subcellular location of putative sortase substrates in Clostridium difficile | Scientific Reports - Nature
2021-09-20 07:00 Risk Factors Associated With Clostridium difficile-Associated Diarrhea - Cureus
2019-04-16 07:00 Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism - ScienceDirect.com
2019-03-07 08:00 Epidemiology of Clostridium difficile infection in hospitalized adults and the first isolation of C. difficile PCR ribotype 027 ... - BioMed Central
2016-07-11 07:00 The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia - Nature
2013-10-17 07:00 Horizontal gene transfer converts non-toxigenic Clostridium difficile strains into toxin producers - Nature
2019-06-27 07:00 Clostridium difficile: Causes, symptoms, and treatment - Medical News Today
2015-10-08 07:00 Clostridium difficile: New Insights into the Evolution of the Pathogenicity Locus | Scientific Reports - Nature
2010-11-30 08:00 Clostridium difficile infection: epidemiology, risk factors and management - Nature
2017-02-08 08:00 Modifying recurrence of Clostridium difficile infection - Nature

2020-02-21 08:00 A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways - ScienceDirect.com
2017-08-29 07:00 Hospital-acquired Clostridium difficile infection in Mainland China: A seven-year (2009–2016) retrospective study in a ... - Nature
2017-12-21 11:36 Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab - ScienceDirect.com
2017-06-13 07:00 Clostridium difficile: Routine diagnostics in the medical laboratory - healthcare-in-europe.com
2018-11-22 04:42 Small-Molecule Allosteric Triggers of Clostridium difficile Toxin B Auto-proteolysis as a Therapeutic Strategy - ScienceDirect.com
2014-01-20 08:00 Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile ... - Nature
2017-12-21 19:06 Endoscopic Imaging of Clostridium diffìcile Colitis - ScienceDirect.com
2017-12-15 03:29 Clostridium difficile infection: Evolution, phylogeny and molecular epidemiology - ScienceDirect.com
2019-01-08 23:56 The Bacterial Chromatin Protein HupA Can Remodel DNA and Associates with the Nucleoid in Clostridium difficile - ScienceDirect.com
2007-03-04 08:00 Autocatalytic cleavage of Clostridium difficile toxin B - Nature

2019-10-25 07:00 Clostridium difficile clade 3 (RT023) have a modified cell surface and contain a large transposable island with novel ... - Nature
2022-01-10 08:00 Agr Quorum Sensing influences the Wood-Ljungdahl pathway in Clostridium autoethanogenum | Scientific Reports - Nature
2018-08-16 21:16 Clostridium difficile–Associated Diarrhea Surveillance results: 2016-2017 - Institut national de santé publique du Québec
2023-03-24 07:00 C. perfringens | CDC - CDC
2019-10-04 07:00 Anaerobic reduction of europium by a Clostridium strain as a strategy for rare earth biorecovery | Scientific Reports - Nature
2021-05-24 07:00 Prevalence and molecular subtyping of Blastocystis in patients with Clostridium difficile infection, Singapore - Parasites ... - BioMed Central
2016-12-19 08:00 The emerging metabolic view of Clostridium difficile pathogenesis - ScienceDirect.com
2016-07-15 07:00 Clostridium Difficile Infection Worsen Outcome of Hospitalized Patients with Inflammatory Bowel Disease | Scientific ... - Nature
2011-09-02 07:00 QuickStats: Rates of Clostridium difficile Infection Among Hospitalized Patients Aged ≥65 Years,* by Age Group ... - CDC
2013-10-04 07:00 Prevalence of Clostridium difficile colonization among healthcare workers - BMC Infectious Diseases - BioMed Central

2018-10-23 07:00 Updated IDSA guideline for treatment of Clostridium difficile infection - Mayo Clinic
2019-01-03 06:10 Fecal Microbiota Transplantation Is Superior to Fidaxomicin for Treatment of Recurrent Clostridium difficile Infection - ScienceDirect.com
2018-01-24 08:00 Leptin receptor q223r polymorphism influences neutrophil mobilization after Clostridium difficile infection | Mucosal ... - Nature
2017-03-27 07:00 Gastric acid suppression medications increase risk for recurrence of Clostridium difficile infection - Mayo Clinic
2019-03-02 00:06 Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides (Clostridium) difficile: Synthesis ... - ScienceDirect.com
2018-09-10 07:00 Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection - Nature
2016-03-09 08:00 Clostridium difficile infection: epidemiology, diagnosis and understanding transmission - Nature

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